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At the first MACS visit, men were Several additional characteristics of interest were time on study and number of receptive and insertive anal sex partnerships, which were abstracted from the data. The implications of this study have clinical relevance in assessing risk factors for HPV pathogenesis, with the goal of directly targeting screening strategies for those most likely to be affected by HPV-related disease. We found a positive association between historical EGWs and new episodes of external genital warts. Future studies should explore these relationships with regard to intra-anal infection and anal intraepithelial neoplasias, and determine whether pharmacological immune reconstitution decreases risk for EGWs and other HPV-related diseases within the context of HIV infection. Specifically, these analyses suggest that smoking, historical occurrences of EGWs, and HIV infection characteristics together differentially influence the risk for new occurrences of genital warts. Los Angeles: References and Notes 1. Cervical dysplasia and HIV infection [letter] J. These analyses are important because, unlike many prior studies, we have sufficient power to detect complex relationships between HPV infection and important clinical exposures: Thus, these reported occurrences may reflect diagnoses made between MACS visits by community clinicians.
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It is likely that we may lack the power to detect a difference between the adjusted risk ratios after we adjusted for the effect of age, partner number, education, time on study, MACS visit sequence, and repeated observations, even if such a difference exists.